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[Hyperbaric oxygenation in the complex treatment of Parkinson disease]
[Article in Russian]
Neretin VIa, Lobov MA, Kotov SV, Cheskidova GF, Molchanova GS.
Hyperbaric oxygenation (HBO) was used for the treatment of 64 patients suffering from
parkinsonism of different etiology. HBO sessions were provided daily, 8-12 per course,
the treatment pressure amounted to 1.3-2 atm exposure to 40-60 minutes. The
beneficial effect was marked in 55 patients. The results of the treatment turned out
better in vascular parkinsonism, in patients under 65 years, with a disease standing of
1-5 years. The akineticorigid syndrome regressed to a greater degree, whereas in
trembling hyperkinesis, HBO turned out to be less potent.
[Article in Russian]
Neretin VIa, Lobov MA, Kotov SV, Cheskidova GF, Molchanova GS.
Hyperbaric oxygenation (HBO) was used for the treatment of 64 patients suffering from
parkinsonism of different etiology. HBO sessions were provided daily, 8-12 per course,
the treatment pressure amounted to 1.3-2 atm exposure to 40-60 minutes. The
beneficial effect was marked in 55 patients. The results of the treatment turned out
better in vascular parkinsonism, in patients under 65 years, with a disease standing of
1-5 years. The akineticorigid syndrome regressed to a greater degree, whereas in
trembling hyperkinesis, HBO turned out to be less potent.
Dis Colon Rectum. 1995 Jun;38(6):609-14.
Hyperbaric oxygenation in severe perineal Crohn's disease.
Colombel JF, Mathieu D, Bouault JM, Lesage X, Zavadil P, Quandalle P, Cortot A.
Clinique des Maladies de l'Appareil Digestif et de la Nutrition, Hopital Huriez, CHRU
Lille, France.
PURPOSE: Perineal involvement in Crohn's disease is a common and distressing
condition, often refractory to medical or surgical treatments. Recent reports suggest
the efficacy of hyperbaric oxygenation (HBO) in the healing of perineal lesions. We
evaluated HBO in severe patients with perineal Crohn's disease. METHODS: Ten
consecutive patients (8 women, 2 men; mean age, 30 years) were studied. There
were four superficial fissures, four cavitating ulcers, six low or superficial fistulas, two
high fistulas, and one irreversible anal stenosis. All patients had received one or
more medical treatments without healing the perineal lesions, and all had had
previous surgery for perineal lesions. RESULTS: Two patients discontinued HBO
after a few sessions and did not complete treatment. Eight patients completed at
least 30 HBO sessions and were evaluable. At the end of the procedure, six of eight
patients treated were healed, three completely and three partially. All patients who
healed completely received HBO as an additional treatment to local perineal surgery.
CONCLUSION: HBO might be useful as a last resort treatment of chronic perineal
Crohn's disease, resistant to other treatments or as a complement to surgery.
Hyperbaric oxygenation in severe perineal Crohn's disease.
Colombel JF, Mathieu D, Bouault JM, Lesage X, Zavadil P, Quandalle P, Cortot A.
Clinique des Maladies de l'Appareil Digestif et de la Nutrition, Hopital Huriez, CHRU
Lille, France.
PURPOSE: Perineal involvement in Crohn's disease is a common and distressing
condition, often refractory to medical or surgical treatments. Recent reports suggest
the efficacy of hyperbaric oxygenation (HBO) in the healing of perineal lesions. We
evaluated HBO in severe patients with perineal Crohn's disease. METHODS: Ten
consecutive patients (8 women, 2 men; mean age, 30 years) were studied. There
were four superficial fissures, four cavitating ulcers, six low or superficial fistulas, two
high fistulas, and one irreversible anal stenosis. All patients had received one or
more medical treatments without healing the perineal lesions, and all had had
previous surgery for perineal lesions. RESULTS: Two patients discontinued HBO
after a few sessions and did not complete treatment. Eight patients completed at
least 30 HBO sessions and were evaluable. At the end of the procedure, six of eight
patients treated were healed, three completely and three partially. All patients who
healed completely received HBO as an additional treatment to local perineal surgery.
CONCLUSION: HBO might be useful as a last resort treatment of chronic perineal
Crohn's disease, resistant to other treatments or as a complement to surgery.
Headache. 1998 Feb;38(2):112-5.
Hyperbaric oxygen in the treatment of migraine with aura.
Wilson JR, Foresman BH, Gamber RG, Wright T.
Department of Integrative Physiology, University of North Texas Health Science
Center, Fort Worth, USA.
Cephalalgia is one of the most common medical complaints and the search continues
for relief. Early treatments for migraine included inhalation of 100% oxygen. It has
been theorized that the increased levels of oxygen in the blood act as an
alpha-adrenergic agent to alleviate headache pain through vasoconstriction and local
metabolic effects. The presence of muscle tenderness during some migraine
headaches has also been established. The purpose of this study was to document
relief of cephalalgia through use of a visual analog pain scale, algometry, and manual
palpation. Female subjects with confirmed migraine were randomly assigned to begin
with either the control (100% oxygen, no pressure) or hyperbaric treatment (100%
oxygen, pressure). Manual palpation and algometry of 10 sites were done, bilaterally,
by a trained specialist. Pain was evaluated with a visual analog scale. Resolution of
tenderness and edema following both treatments was observable by manual
palpation while algometry showed no differences between the two. Subjective pain
was significantly decreased following hyperbaric oxygen treatment but not following
the control treatment. Results suggest that hyperbaric oxygen treatment reduces
migraine headache pain and that the patient's subjective assessment was the best
indicator of relief.
Hyperbaric oxygen in the treatment of migraine with aura.
Wilson JR, Foresman BH, Gamber RG, Wright T.
Department of Integrative Physiology, University of North Texas Health Science
Center, Fort Worth, USA.
Cephalalgia is one of the most common medical complaints and the search continues
for relief. Early treatments for migraine included inhalation of 100% oxygen. It has
been theorized that the increased levels of oxygen in the blood act as an
alpha-adrenergic agent to alleviate headache pain through vasoconstriction and local
metabolic effects. The presence of muscle tenderness during some migraine
headaches has also been established. The purpose of this study was to document
relief of cephalalgia through use of a visual analog pain scale, algometry, and manual
palpation. Female subjects with confirmed migraine were randomly assigned to begin
with either the control (100% oxygen, no pressure) or hyperbaric treatment (100%
oxygen, pressure). Manual palpation and algometry of 10 sites were done, bilaterally,
by a trained specialist. Pain was evaluated with a visual analog scale. Resolution of
tenderness and edema following both treatments was observable by manual
palpation while algometry showed no differences between the two. Subjective pain
was significantly decreased following hyperbaric oxygen treatment but not following
the control treatment. Results suggest that hyperbaric oxygen treatment reduces
migraine headache pain and that the patient's subjective assessment was the best
indicator of relief.
Lupus. 1995 Jun;4(3):172-5.
Use of hyperbaric oxygen in rheumatic diseases: case report and critical
analysis.
Wallace DJ, Silverman S, Goldstein J, Hughes D.
Department of Medicine, Cedars-Sinai Medical Centre, Los Angeles, CA, USA.
Hyperbaric oxygen has been used in patients with rheumatic disease for many years
without reports of untoward or unusual complications for a variety of non-rheumatic
indications. Recent evidence that hyperbaric oxygen inhibits the actions of certain
cytokines, acts as an immune modulator and may help cognitive dysfunction has
resulted in a re-examination of its potential role in rheumatic diseases. A case report
of a lupus/scleroderma crossover patient is presented whose cognitive dysfunction
improved after hyperbaric oxygen therapy. The history of hyperbaric oxygen and its
physiology are related, along with a focused review of its effects on the immune and
central nervous systems. Areas which might warrant further consideration by
rheumatologists are outlined, as well as areas of concern.
Use of hyperbaric oxygen in rheumatic diseases: case report and critical
analysis.
Wallace DJ, Silverman S, Goldstein J, Hughes D.
Department of Medicine, Cedars-Sinai Medical Centre, Los Angeles, CA, USA.
Hyperbaric oxygen has been used in patients with rheumatic disease for many years
without reports of untoward or unusual complications for a variety of non-rheumatic
indications. Recent evidence that hyperbaric oxygen inhibits the actions of certain
cytokines, acts as an immune modulator and may help cognitive dysfunction has
resulted in a re-examination of its potential role in rheumatic diseases. A case report
of a lupus/scleroderma crossover patient is presented whose cognitive dysfunction
improved after hyperbaric oxygen therapy. The history of hyperbaric oxygen and its
physiology are related, along with a focused review of its effects on the immune and
central nervous systems. Areas which might warrant further consideration by
rheumatologists are outlined, as well as areas of concern.
Surgery. 1990 Nov;108(5):847-50.
Hyperbaric oxygen therapy for necrotizing fasciitis reduces mortality and the
need for debridements.
Riseman JA, Zamboni WA, Curtis A, Graham DR, Konrad HR, Ross DS.
Memorial Medical Center, Southern Illinois University, Springfield.
Twenty-nine patients with necrotizing fasciitis were treated from 1980 to 1988. This
study evaluates how the addition of hyperbaric oxygen (HBO) therapy to surgical
treatment has affected mortality and the number of debridements required to achieve
wound control in these patients. Two groups of patients were viewed: group 1 (n =
12) received surgical debridement and antibiotics only; group 2 (n = 17) received
HBO (90 minutes at 2.5 atm, average 7.4 treatments) in addition to surgery and
antibiotics. Both groups were similar in age, race, sex, wound bacteriology, and
antimicrobial therapy. Body surface area affected was similar, however, perineal
involvement was more common in group 2 (53%) than in group 1 (12%). The
admitting conditions of patients in group 1 (non-HBO) were diabetic, 33%; white
blood cell count more than 12,000, 50%; and shock, 8%. The admitting conditions of
patients in group 2 (HBO) were diabetic, 47%; white blood cell count more than
12,000, 59%; and shock, 29%. Although group 2 patients receiving HBO were more
seriously ill on admission, mortality was significantly lower (23%) compared to group
1 (66%) (p less than 0.02). In addition, only 1.2 debridements per group 2 patient
were required to achieve wound control versus 3.3 debridements per group 1 patient
(p less than 0.03). The addition of HBO therapy to the surgical and antimicrobial
treatment of necrotizing fasciitis significantly reduced mortality and wound morbidity
(number of debridements) in this study, especially among nonclostridial infections.
We conclude that HBO should be used routinely in the treatment of necrotizing
fasciitis.
Hyperbaric oxygen therapy for necrotizing fasciitis reduces mortality and the
need for debridements.
Riseman JA, Zamboni WA, Curtis A, Graham DR, Konrad HR, Ross DS.
Memorial Medical Center, Southern Illinois University, Springfield.
Twenty-nine patients with necrotizing fasciitis were treated from 1980 to 1988. This
study evaluates how the addition of hyperbaric oxygen (HBO) therapy to surgical
treatment has affected mortality and the number of debridements required to achieve
wound control in these patients. Two groups of patients were viewed: group 1 (n =
12) received surgical debridement and antibiotics only; group 2 (n = 17) received
HBO (90 minutes at 2.5 atm, average 7.4 treatments) in addition to surgery and
antibiotics. Both groups were similar in age, race, sex, wound bacteriology, and
antimicrobial therapy. Body surface area affected was similar, however, perineal
involvement was more common in group 2 (53%) than in group 1 (12%). The
admitting conditions of patients in group 1 (non-HBO) were diabetic, 33%; white
blood cell count more than 12,000, 50%; and shock, 8%. The admitting conditions of
patients in group 2 (HBO) were diabetic, 47%; white blood cell count more than
12,000, 59%; and shock, 29%. Although group 2 patients receiving HBO were more
seriously ill on admission, mortality was significantly lower (23%) compared to group
1 (66%) (p less than 0.02). In addition, only 1.2 debridements per group 2 patient
were required to achieve wound control versus 3.3 debridements per group 1 patient
(p less than 0.03). The addition of HBO therapy to the surgical and antimicrobial
treatment of necrotizing fasciitis significantly reduced mortality and wound morbidity
(number of debridements) in this study, especially among nonclostridial infections.
We conclude that HBO should be used routinely in the treatment of necrotizing
fasciitis.